What Is 2-DG, The New Anti-Covid Drug Made By DRDO And Given Emergency Use Approval In India? All you need to know
DCGI has granted approval for emergency use of a drug developed by Defence Research and Development Organisation (DRDO) to treat Covid-19. DRDO with the help of Hyderabad-based Dr Reddy’s Laboratories has developed the anti-Covid therapeutic application of the drug 2-deoxy-D-glucose (2-DG). A higher proportion of patients treated with the drug tested negative for Covid in RT-PCR tests.
- DCGI granted emergency use approval to DRDO’s 2-DG drug on Saturday
- 2-DG helps in faster recovery of hospitalized patients and reduces supplemental oxygen dependence
- Phase-III trials for 2-DG drug were conducted at 27 Covid hospitals across the country
The Drug Controller General of India has approved an anti-Covid oral drug for emergency use as an adjunct therapy. So far, there was no drug to treat Covid-19 specifically. The treatment revolved around addressing the symptoms of Covid-19 through drugs like Ivermectin. As2-DG’s use has been approved as an adjunct therapy, the drug will be used along with the primary treatment.
2-Deoxy-d-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level.
Here is everything you want to know about 2-DG
- The name of the drug is 2-deoxy-D glucose or 2-DG. It has been developed by the Defence Research and Development Organisation, Institute of Nuclear Medicine and Allied Sciences and Dr Reddy’s Laboratories.
- This will help in a faster recovery of Covid-19 patients who are hospitalised.
- This will also ensure that Covid-19 patients do not need oxygen supplement.
- The drug is expected to be effective in patients aged more than 65 years.
- DRDO scientist Dr Anant Narayan Bhatt told ANI that the drug is expected to be effective on different variants also.
- The drug can be produced in bulk in the country as it is a generic module and analogue of glucose.
- The drug accumulates in the cells affected by the virus and stops the growth of the virus. It stops viral synthesis and energy production.
- The drug comes in powder form inside sachets. The patients will have to take it orally dissolving it in water.
Who developed 2-DG?
The drug 2-deoxy-D-glucose (2-DG) has been developed by DRDO’s Institute of Nuclear Medicine and Allied Sciences (INMAS) in collaboration with Hyderabad-based Dr Reddy’s Laboritories.
What do we know about clinical trials for 2-DG?
Phase-II trials for the 2-DG drug were conducted between May and October of last year. Six hospitals were part of the Phase-II (a) trials and 11 hospitals were part of the Phase-II (b) trials to determine dose range.
A total of 110 patients were part of the Phase-II clinical trials of this drug. In terms of improvement in vital signs of symptomatic patients who were administered the drug, a difference of 2.5 days was seen compared to Standard of Care (SoC).
Approval for Phase-III trials was given in November of last year. These trials were conducted at 27 Covid hospitals in Delhi, Uttar Pradesh, West Bengal, Gujarat, Rajasthan, Maharashtra, Andhra Pradesh, Telangana, Karnataka and Tamil Nadu.
How does 2-DG work?
Broadly, you can classify 2-DG as an antiviral, but in the true sense, it is not an antiviral because it is not killing the virus. It only gets aggregated inside the cell and cuts off the growth material required for the virus to grow. In the classical sense, therefore, one cannot call it an antiviral.
How can 2-DG be consumed?
Currently, the drug comes in powder form, in a sachet, which is taken orally by dissolving it in water. Since it has been approved for emergency use only, it has to be administered under supervised care. As per findings, a higher proportion of patients treated with the drug tested negative for Covid in RT-PCR tests.
Will 2-DG have a significant impact?
The DRDO says that the 2-deoxy-D-glucose (2-DG) drug can easily be produced and made available in plenty in the country since it is a generic molecule and analogue of glucose.